Although empirically supported treatments for posttraumatic stress disorder (PTSD) produce reductions in symptoms, they have less impact on functional impairment (Schnurr et al., 2003). Accordingly, identifying intervention targets beyond PTSD that may alleviate functional impairment is critical to enhancing treatment outcomes. Preliminary findings suggest negative mood regulation and interpersonal problems account for variance in functional impairment after controlling for PTSD symptoms (Cloitre, Miranda, Stovall-McClough, & Han, 2005). Given that these associations have only been studied with respect to global functioning deficits, the current study aimed to establish links among negative mood regulation and interpersonal problems in relation to trauma-related functional impairment (TRFI). Trauma-exposed undergraduates (N = 213) completed measures of PTSD symptom severity, TRFI, negative mood regulation, and interpersonal problems. Greater TRFI was significantly associated with greater PTSD symptom severity, poorer negative mood regulation, and greater interpersonal problems. When examined within a structural model, PTSD symptoms accounted for 42.9% of the variance in TRFI. Negative mood regulation and interpersonal problems accounted for an additional 13.1% of the variance in TRFI after controlling for PTSD symptoms. Results of the present study replicate and extend previous findings and highlight these constructs as potentially salient targets for intervention. (PsycINFO Database Record (c) 2019 APA, all rights reserved)