Stem Cells Model Genetic Risk for Developing Alzheimer’s Disease

This shows a statue of a headStem cell study reveals astrocytes carrying the Alzheimer’s associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta production and how the oversupply of cholesterol associated with APOE4 astrocytes may promote amyloid-beta formation in Alzheimer’s patients.